PMID:789358

Citation	Foulds, J (1976) TolF locus in Escherichia coli: chromosomal location and relationship to loci cmlB and tolD.J. Bacteriol. 128:604-8
Abstract	The tentative map position on the Escherichia coli chromosome of the tolF locus, determining tolerance to colicins A, E2, E3, K, and L, has been confirmed by three-point transduction. It lies between the aroA and pyrD loci at about 21 min on the linkage map of Bachmann et al. (1976). The cmlB locus, determining increased resistance to the antibiotics chloramphenicol and tetracycline, also lies in this region (Reeve, 1966). Phenotypic and genetic comparison of isogenic strains that carry a mutation in either the tolF or cmlB locus makes it likely that these loci are closely related or identical. The tolD locus determining tolerance to colicins E2 and E3 as well as increased resistance to antibiotics has been reported to be located close to the aroA locus as a result of conjugation experiments (Eriksson-Grennberg et al. 1965). However, tolD did not cotransduce with any of several loci in this region, indicating that the mutation is not located within the region of the genetic map corresponding to approximately 19 to 22.5 min.
Links	PubMed
Keywords	Chromosome Mapping; Chromosomes, Bacterial; Colicins; Drug Resistance, Microbial; Escherichia coli; Genes; Genetic Complementation Test; Genetic Linkage; Phenotype; Plasmids; Transduction, Genetic
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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:					Resistance to Colicin A, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:					Resistance to Colicin E2, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:					Resistance to Colicin E3, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:					Resistance to Colicin K, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:					Resistance to Colicin L, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:					Resistance to Colicin L-JF246, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Resistance to Chloramphenicol, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Resistance to Tetracycline, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Resistance to oxytetracycline, table 5
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: JF557 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Resistance to polymyxin, table 5
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