PMID: 19103924

Citation	No author listed (2009) Conditional essentiality of the csrA gene in Escherichia coli. J. Bacteriol. 191:1722-4
Abstract	CsrA is a global posttranscriptional regulator of numerous physiological processes, such as glycogenesis and glycolysis. Here, we show that the csrA gene of Escherichia coli is essential for growth on LB and on synthetic medium containing glycolytic carbon sources. However, csrA is not necessary for growth on synthetic medium containing pyruvate, showing that the Krebs cycle is functional in the csrA::cat deletion mutant. Deletion of the glgCAP operon in the csrA::cat mutant restored the ability to grow on LB and on synthetic medium containing glycolytic carbon sources, showing that growth inhibition is due to an excess of glycogen synthesis.
Links	PubMed PMC2648183 Online version:10.1128/JB.01573-08
Keywords	Culture Media/chemistry; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Deletion; Gene Expression Regulation, Bacterial; Genes, Essential; Glycogen/metabolism; Glycogen Storage Disease; Glycolysis; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism
edit table

Main Points of the Paper

Please summarize the main points of the paper.

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

See Help:AnnotationTable for details on how to edit this table.
<protect>

Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
edit table

</protect>

See Help:References for how to manage references in omp dev.