PMID:352805

Citation	Shakulov, RS, Livshits, VA, Zaigraeva, GG, Lideman, LF and Mukhamed'ianova, TD (1978) [Partial suppression of the effect of gene re1A in Fusr-mutant Escherichia coli K-12 cells]. Genetika 14:890-9
Abstract	Mutants of Escherichia coli K-12 re1A+-strain CP 78 resistant to fusidic acid (Fusr) were isolated and forms sensitive to high concentration of leucine (500 g/ml) were selected. When shifted down from nutrient broth to minimal medium M9 with supplemented glucose and required amino acids, these leucine-sensitive mutants continued RNA synthesis and demonstrated the prolonged lag-phase in contrast to the parent strain CP 78. Both properties are known to be characteristic of the Rel- strains. At the same time withdrawal of the required amino acids results in cessation of RNA synthesis in Fusr mutants, in the parent Rel+ strain. Thus, leucine-sensitive Fusr mutants show Rel- phenotype only upon amino acid starvation caused by shift down from nutrient broth to minimal medium.
Links	PubMed
Keywords	Adaptation, Physiological; Bacterial Proteins/biosynthesis; Drug Resistance, Microbial; Escherichia coli/drug effects; Escherichia coli/genetics; Fusidic Acid/pharmacology; Genes; Leucine/pharmacology; Mutation; RNA, Bacterial/biosynthesis
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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
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