Difference between revisions of "PMID:4908785"

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'''Benson, CE, Love, SH and Remy, CN'''  (1970) Inhibition of de novo purine biosynthesis and interconversion by 6-methylpurine in Escherichia coli.''J. Bacteriol.'' '''101''':872-80
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!align=left  |Abstract
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The inhibition of Escherichia coli strain B and strain W-11 by 6-methylpurine depended on the formation of 6-methylpurine ribonucleotide by the action of adenine phosphoribosyltransferase (AMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.7). 6-Methylpurine ribonucleotide inhibited the de novo synthesis of purines, presumably via pseudofeedback inhibition of phosphoribosylpyrophosphate amidotransferase (EC 2.4.2.14). The same mechanism accounted for its inhibition of adenylosuccinate synthetase [IMP: l-aspartate ligase (GDP), EC 6.3.4.4]. Adenine and 6-methylaminopurine prevented inhibition by competing for the action of adenine phosphoribosyltransferase. In addition, adenine reversed this inhibition by replenishing the AMP to bypass both sites of inhibition. Nonproliferating suspensions of strain B-94, which lacked adenylosuccinate lyase (EC 4.3.2.2), converted exogenous hypoxanthine and aspartate to succinoadenine derivatives which accumulated in the medium. Compounds which inhibited adenylosuccinate synthetase inhibited accumulation of the succinoadenine derivatives. A method was described for the isolation of mutants which potentially possessed an altered adenylosuccinate synthetase.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4908785 PubMed]
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!align=left  |Keywords
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Adenine; Carbon Isotopes; Chromatography, Paper; Depression, Chemical; Electrophoresis; Escherichia coli; Genetics, Microbial; Ligases; Lyases; Mutation; Purines; Spectrophotometry; Transferases; Ultraviolet Rays
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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{|  id="U4f762292a2559"  class=" tableEdit Phenotype_Table_2" 
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: B and W-11
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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*Genotype of Reference Strain: ''purA''
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*Genotype of Experimental Strain : ''purA''
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*Reference Condition:
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Resistance to Methyl(6)purine + hypoxanthine
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==Notes==
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==References==
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[[Category:Publication]] [[Category:LaRossa citations that need review]] [[Category:Papers referenced in the LaRossa chapter]]

Latest revision as of 16:18, 30 March 2012

Citation

Benson, CE, Love, SH and Remy, CN (1970) Inhibition of de novo purine biosynthesis and interconversion by 6-methylpurine in Escherichia coli.J. Bacteriol. 101:872-80

Abstract

The inhibition of Escherichia coli strain B and strain W-11 by 6-methylpurine depended on the formation of 6-methylpurine ribonucleotide by the action of adenine phosphoribosyltransferase (AMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.7). 6-Methylpurine ribonucleotide inhibited the de novo synthesis of purines, presumably via pseudofeedback inhibition of phosphoribosylpyrophosphate amidotransferase (EC 2.4.2.14). The same mechanism accounted for its inhibition of adenylosuccinate synthetase [IMP: l-aspartate ligase (GDP), EC 6.3.4.4]. Adenine and 6-methylaminopurine prevented inhibition by competing for the action of adenine phosphoribosyltransferase. In addition, adenine reversed this inhibition by replenishing the AMP to bypass both sites of inhibition. Nonproliferating suspensions of strain B-94, which lacked adenylosuccinate lyase (EC 4.3.2.2), converted exogenous hypoxanthine and aspartate to succinoadenine derivatives which accumulated in the medium. Compounds which inhibited adenylosuccinate synthetase inhibited accumulation of the succinoadenine derivatives. A method was described for the isolation of mutants which potentially possessed an altered adenylosuccinate synthetase.

Links

PubMed

Keywords

Adenine; Carbon Isotopes; Chromatography, Paper; Depression, Chemical; Electrophoresis; Escherichia coli; Genetics, Microbial; Ligases; Lyases; Mutation; Purines; Spectrophotometry; Transferases; Ultraviolet Rays

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Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

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<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: B and W-11
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: purA
  • Genotype of Experimental Strain : purA
  • Reference Condition:

Resistance to Methyl(6)purine + hypoxanthine


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</protect>

Notes

References

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