PMID:353502

Citation	Thorbjarnardóttir, SH, Magnúsdóttir, RA and Eggertsson, G (1978) Mutations determining generalized resistance to aminoglycoside antibiotics in Escherichia coli.Mol. Gen. Genet. 161:89-98
Abstract	Mutations conferring resistance to low levels of kanamycin in Escherichia coli have been mapped at 3 locations: the unc locus (min. 83), a locus we have designated kanA (MIN. 72), close to strA (rpsL), and a locus at min. 86.5 previously discovered by Plate (1976) that we have designated ecfB. The unc and ecfB mutations are associated with defects in energy metabolism, while mutations at kanA may be in the gene coding for ribosomal protein S12 (rpsL). The three types of mutations cause cross resistance to a number of different aminoglycoside antibiotics and the effects of the mutations are cumulative in combination.
Links	PubMed
Keywords	Ampicillin; Chloramphenicol; Chromosome Mapping; Chromosomes, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Genes; Kanamycin; Penicillin Resistance; Tetracycline; Transduction, Genetic
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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: GE444 NCBI Taxon ID: 83333	Genotype of Reference Strain: ecfB Genotype of Experimental Strain : ecfB1	Reference Condition:					Resistance to 90 micrograms/ml Kanamycin
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