PMID:6344786

Citation	Jaffé, A, Chabbert, YA and Derlot, E (1983) Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants.Antimicrob. Agents Chemother. 23:622-5
Abstract	beta-Lactam-resistant mutants of Escherichia coli K-12 were selected by using 12 different beta-lactam derivatives. The mutants fell into three categories showing (i) altered permeation through reduction or loss of outer membrane porin proteins (including ompF, ompR, and envZ alleles); (ii) increase in the rate of synthesis of chromosomally mediated beta-lactamase; or (iii) defective synthesis or action of cyclic adenosine 3',5'-phosphate (cya and crp alleles).
Links	PubMed
Keywords	Anti-Bacterial Agents; Drug Resistance, Microbial; Escherichia coli; Mutation; beta-Lactamases; beta-Lactams
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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: B1389 NCBI Taxon ID: 83333	Genotype of Reference Strain: crp Genotype of Experimental Strain : crp in strain B1558	Reference Condition:					Resistance to Beta Lactams
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References

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