Difference between revisions of "PMID:2847279"

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{|  id="L5022aeb8201b2"  class=" tableEdit PMID_info_table" 
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'''Bouloc, P, Jaffé, A and D'Ari, R''' Preliminary physiologic characterization and genetic analysis of a new Escherichia coli mutant, lov, resistant to mecillinam.''Rev. Infect. Dis.'' '''10''':905-10
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!align=left  |Abstract
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A mutant of Escherichia coli resistant to mecillinam was selected. The target of this antibiotic is penicillin-binding protein 2 (PBP2), which is active in cell wall elongation and responsible for the rod-like shape of the organism. Several observations indicate that PBP2 remains active in the mutant. For example, cells are small and rod-shaped in the absence of mecillinam but become spherical in its presence; the formation of filaments in the presence of furazlocillin shows that cell wall elongation still takes place. The mutant also has a low growth rate and small cell volume, even in rich medium. In these respects, the mutant resembles cya or crp strains (in which the cyclic adenosine monophosphate-catabolite activator protein [cAMP-CAP] complex is inactive), although its catabolic capacities are unaffected. The mutation, called lov, lies at 41 minutes on the E. coli genetic map. The phenotype is partially suppressed by the P1-mediated transduction of an rpsL ribosomal mutation conferring streptomycin resistance.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2847279 PubMed]
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!align=left  |Keywords
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Amdinocillin; Bacterial Proteins; Carrier Proteins; Culture Media; Cyclic AMP; Escherichia coli; Hexosyltransferases; Multienzyme Complexes; Muramoylpentapeptide Carboxypeptidase; Mutation; Penicillin Resistance; Penicillin-Binding Proteins; Peptidyl Transferases; Phenotype; Transduction, Genetic
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==Main Points of the Paper ==
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== Materials and Methods Used ==
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==Phenotype Annotations==
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==Notes==
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==References==
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[[Category:Publication]]

Revision as of 13:23, 8 August 2012

Citation

Bouloc, P, Jaffé, A and D'Ari, R Preliminary physiologic characterization and genetic analysis of a new Escherichia coli mutant, lov, resistant to mecillinam.Rev. Infect. Dis. 10:905-10

Abstract

A mutant of Escherichia coli resistant to mecillinam was selected. The target of this antibiotic is penicillin-binding protein 2 (PBP2), which is active in cell wall elongation and responsible for the rod-like shape of the organism. Several observations indicate that PBP2 remains active in the mutant. For example, cells are small and rod-shaped in the absence of mecillinam but become spherical in its presence; the formation of filaments in the presence of furazlocillin shows that cell wall elongation still takes place. The mutant also has a low growth rate and small cell volume, even in rich medium. In these respects, the mutant resembles cya or crp strains (in which the cyclic adenosine monophosphate-catabolite activator protein [cAMP-CAP] complex is inactive), although its catabolic capacities are unaffected. The mutation, called lov, lies at 41 minutes on the E. coli genetic map. The phenotype is partially suppressed by the P1-mediated transduction of an rpsL ribosomal mutation conferring streptomycin resistance.

Links

PubMed

Keywords

Amdinocillin; Bacterial Proteins; Carrier Proteins; Culture Media; Cyclic AMP; Escherichia coli; Hexosyltransferases; Multienzyme Complexes; Muramoylpentapeptide Carboxypeptidase; Mutation; Penicillin Resistance; Penicillin-Binding Proteins; Peptidyl Transferases; Phenotype; Transduction, Genetic

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Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status
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</protect>

Notes

References

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