Difference between revisions of "PMID:353502"
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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*Taxon: Escherichia coli | *Taxon: Escherichia coli | ||
*Strain: K-12 | *Strain: K-12 | ||
| − | *Substrain: | + | *Substrain: AB663 |
*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&lin=f&keep=1&srchmode=1&unlock 83333] | *NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&lin=f&keep=1&srchmode=1&unlock 83333] | ||
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*Genotype of Reference Strain: ''ecfB'' | *Genotype of Reference Strain: ''ecfB'' | ||
| − | *Genotype of Experimental Strain : ''ecfB1'' | + | *Genotype of Experimental Strain : ''ecfB1 kanA10'' in strain GE442 |
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*Reference Condition: | *Reference Condition: | ||
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| − | + | 0000276 | |
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| − | + | increased resistance to antimicrobial compound | |
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| − | Resistance to 90 micrograms/ml Kanamycin | + | Resistance to 90 micrograms/ml Kanamycin . |
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Latest revision as of 13:18, 24 January 2013
| Citation |
Thorbjarnardóttir, SH, Magnúsdóttir, RA and Eggertsson, G (1978) Mutations determining generalized resistance to aminoglycoside antibiotics in Escherichia coli.Mol. Gen. Genet. 161:89-98 |
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| Abstract |
Mutations conferring resistance to low levels of kanamycin in Escherichia coli have been mapped at 3 locations: the unc locus (min. 83), a locus we have designated kanA (MIN. 72), close to strA (rpsL), and a locus at min. 86.5 previously discovered by Plate (1976) that we have designated ecfB. The unc and ecfB mutations are associated with defects in energy metabolism, while mutations at kanA may be in the gene coding for ribosomal protein S12 (rpsL). The three types of mutations cause cross resistance to a number of different aminoglycoside antibiotics and the effects of the mutations are cumulative in combination. |
| Links | |
| Keywords |
Ampicillin; Chloramphenicol; Chromosome Mapping; Chromosomes, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Genes; Kanamycin; Penicillin Resistance; Tetracycline; Transduction, Genetic |
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Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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0000276 |
increased resistance to antimicrobial compound |
Resistance to 90 micrograms/ml Kanamycin . |
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</protect>
Notes
ECOID: Term for Solid in vivo assay is awaiting approval and # assignment.
OMP term: Term is up for discussion in meeting awaiting for term request and eventually being assigned in the tree.
References
See Help:References for how to manage references in omp dev.
