Difference between revisions of "PMID:6998971"

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{|  id="H4f4bd160c4000"  class=" tableEdit PMID_info_table" 
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!align=left  |Citation
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'''Ferenci, T'''  (1980) Methyl-alpha-maltoside and 5-thiomaltose: analogs transported by the Escherichia coli maltose transport system.''J. Bacteriol.'' '''144''':7-11
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!align=left  |Abstract
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Neither methyl-alpha-maltoside nor 5-thiomaltose is utilized by Escherichia coli as a sole carbon source. Both are, however, effective competitive inhibitors of maltose transport into the bacterium (Km for maltose, 0.8 microM, Ki for methyl-alpha-maltoside, 5.5 microM; Ki for 5-thiomaltose, 0.2 microM). Both analogs are bound by the periplasmic maltose-binding protein. Methyl-alpha-[14C]maltoside and 5-[3H]thiomaltose were both accumulated inside E. coli. Methyl-alpha-maltoside was unchanged after accumulation, but 5-thiomaltose was converted to an unidentified compound that could exit from the bacterium. Both analogs were inhibitory to the growth of E. coli, but only when the bacteria were previously induced for the maltose transport system. The analogs are substrates for but poor inducers of the maltose transport system.
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!align=left  |Links
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6998971 PubMed]
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!align=left  |Keywords
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Biological Transport; Carrier Proteins; Escherichia coli; Maltose; Membrane Proteins
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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{{AnnotationTableHelp}}
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{|  id="Q4f4bd1610682a"  class=" tableEdit Phenotype_Table_2" 
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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*Genotype of Reference Strain: ''malE''
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*Genotype of Experimental Strain : ''malE(del)''
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*Reference Condition:
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OMP:0000284
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loss of utilization of carbon-containing compound
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ECO:0000033
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traceable author statement
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Thio(5)maltose increase resistance for selection for mutant maltose transport system.
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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*Genotype of Reference Strain: ''malF''
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*Genotype of Experimental Strain : ''malF(del)''
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*Reference Condition:
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OMP:0000284
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loss of utilization of carbon-containing compound
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ECO:0000033
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traceable author statement
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Thio(5)maltose increase resistance for selection for mutant maltose transport system.
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|-
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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*Genotype of Reference Strain: ''malG''
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*Genotype of Experimental Strain : ''malG(del)''
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*Reference Condition:
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OMP:0000284
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loss of utilization of carbon-containing compound
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ECO:0000033
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traceable author statement
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Thio(5)maltose increase resistance for selection for mutant maltose transport system.
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|-
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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*Genotype of Reference Strain: ''malK''
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*Genotype of Experimental Strain : ''malK(del)''
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*Reference Condition:
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|
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OMP:0000284
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|
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loss of utilization of carbon-containing compound
 +
|
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ECO:0000033
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|
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traceable author statement
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|
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Thio(5)maltose resistance.
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|
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|-
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|
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a mutation or genetic difference within a strain
 +
|
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*Taxon: Escherichia coli
 +
*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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|
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*Genotype of Reference Strain: ''malT''
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*Genotype of Experimental Strain : ''malT(del)''
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|
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*Reference Condition:
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|
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OMP:0000284
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|
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loss of utilization of carbon-containing compound
 +
|
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ECO:0000033
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|
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traceable author statement
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|
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Thio(5)maltose resistance.
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|
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|- class="tableEdit_footer"
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|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=d41d8cd98f00b204e9800998ecf8427e.2866.Q4f4bd1610682a&page=2866&pagename={{FULLPAGENAMEE}}&type=0&template=Phenotype_Table_2 edit table]</span> || || || || || || || || ||
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==Notes==
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==References==
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{{RefHelp}}
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<references/>
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[[Category:Publication]] [[Category:Papers referenced in the LaRossa chapter]]

Latest revision as of 11:21, 30 April 2012

Citation

Ferenci, T (1980) Methyl-alpha-maltoside and 5-thiomaltose: analogs transported by the Escherichia coli maltose transport system.J. Bacteriol. 144:7-11

Abstract

Neither methyl-alpha-maltoside nor 5-thiomaltose is utilized by Escherichia coli as a sole carbon source. Both are, however, effective competitive inhibitors of maltose transport into the bacterium (Km for maltose, 0.8 microM, Ki for methyl-alpha-maltoside, 5.5 microM; Ki for 5-thiomaltose, 0.2 microM). Both analogs are bound by the periplasmic maltose-binding protein. Methyl-alpha-[14C]maltoside and 5-[3H]thiomaltose were both accumulated inside E. coli. Methyl-alpha-maltoside was unchanged after accumulation, but 5-thiomaltose was converted to an unidentified compound that could exit from the bacterium. Both analogs were inhibitory to the growth of E. coli, but only when the bacteria were previously induced for the maltose transport system. The analogs are substrates for but poor inducers of the maltose transport system.

Links

PubMed

Keywords

Biological Transport; Carrier Proteins; Escherichia coli; Maltose; Membrane Proteins

edit table

Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: malE
  • Genotype of Experimental Strain : malE(del)
  • Reference Condition:

OMP:0000284

loss of utilization of carbon-containing compound

ECO:0000033

traceable author statement

Thio(5)maltose increase resistance for selection for mutant maltose transport system.

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: malF
  • Genotype of Experimental Strain : malF(del)
  • Reference Condition:

OMP:0000284

loss of utilization of carbon-containing compound

ECO:0000033

traceable author statement

Thio(5)maltose increase resistance for selection for mutant maltose transport system.

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: malG
  • Genotype of Experimental Strain : malG(del)
  • Reference Condition:

OMP:0000284

loss of utilization of carbon-containing compound

ECO:0000033

traceable author statement

Thio(5)maltose increase resistance for selection for mutant maltose transport system.

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: malK
  • Genotype of Experimental Strain : malK(del)
  • Reference Condition:

OMP:0000284

loss of utilization of carbon-containing compound

ECO:0000033

traceable author statement

Thio(5)maltose resistance.

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: malT
  • Genotype of Experimental Strain : malT(del)
  • Reference Condition:

OMP:0000284

loss of utilization of carbon-containing compound

ECO:0000033

traceable author statement

Thio(5)maltose resistance.


edit table

</protect>

Notes

References

See Help:References for how to manage references in omp dev.

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