Difference between revisions of "PMID:353502"

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{|  id="M4fe8f312bd960"  class=" tableEdit PMID_info_table" 
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!align=left  |Citation
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'''Thorbjarnardóttir, SH, Magnúsdóttir, RA and Eggertsson, G'''  (1978) Mutations determining generalized resistance to aminoglycoside antibiotics in Escherichia coli.''Mol. Gen. Genet.'' '''161''':89-98
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!align=left  |Abstract
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Mutations conferring resistance to low levels of kanamycin in Escherichia coli have been mapped at 3 locations: the unc locus (min. 83), a locus we have designated kanA (MIN. 72), close to strA (rpsL), and a locus at min. 86.5 previously discovered by Plate (1976) that we have designated ecfB. The unc and ecfB mutations are associated with defects in energy metabolism, while mutations at kanA may be in the gene coding for ribosomal protein S12 (rpsL). The three types of mutations cause cross resistance to a number of different aminoglycoside antibiotics and the effects of the mutations are cumulative in combination.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=353502 PubMed]
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!align=left  |Keywords
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Ampicillin; Chloramphenicol; Chromosome Mapping; Chromosomes, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Genes; Kanamycin; Penicillin Resistance; Tetracycline; Transduction, Genetic
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="G4fe8f312cf686"  class=" tableEdit Phenotype_Table_2" 
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: AB663
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''ecfB''
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*Genotype of Experimental Strain : ''ecfB1 kanA10'' in strain GE442
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*Reference Condition:
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0000276
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increased resistance to antimicrobial compound
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Resistance to 90 micrograms/ml Kanamycin .
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==Notes==
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ECOID: Term for Solid in vivo assay is awaiting approval and # assignment.
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OMP term: Term is up for discussion in meeting awaiting for term request and eventually being assigned in the tree.
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==References==
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[[Category:Publication]] [[Category:Papers referenced in the LaRossa chapter]] [[Category:LaRossa citations that need review]]

Latest revision as of 13:18, 24 January 2013

Citation

Thorbjarnardóttir, SH, Magnúsdóttir, RA and Eggertsson, G (1978) Mutations determining generalized resistance to aminoglycoside antibiotics in Escherichia coli.Mol. Gen. Genet. 161:89-98

Abstract

Mutations conferring resistance to low levels of kanamycin in Escherichia coli have been mapped at 3 locations: the unc locus (min. 83), a locus we have designated kanA (MIN. 72), close to strA (rpsL), and a locus at min. 86.5 previously discovered by Plate (1976) that we have designated ecfB. The unc and ecfB mutations are associated with defects in energy metabolism, while mutations at kanA may be in the gene coding for ribosomal protein S12 (rpsL). The three types of mutations cause cross resistance to a number of different aminoglycoside antibiotics and the effects of the mutations are cumulative in combination.

Links

PubMed

Keywords

Ampicillin; Chloramphenicol; Chromosome Mapping; Chromosomes, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Genes; Kanamycin; Penicillin Resistance; Tetracycline; Transduction, Genetic

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Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: AB663
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: ecfB
  • Genotype of Experimental Strain : ecfB1 kanA10 in strain GE442
  • Reference Condition:

0000276

increased resistance to antimicrobial compound

Resistance to 90 micrograms/ml Kanamycin .


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</protect>

Notes

ECOID: Term for Solid in vivo assay is awaiting approval and # assignment.

OMP term: Term is up for discussion in meeting awaiting for term request and eventually being assigned in the tree.

References

See Help:References for how to manage references in omp dev.

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