Difference between revisions of "PMID:340907"

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{|  id="Q4fff55bc53ce2"  class=" tableEdit PMID_info_table" 
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'''Pardo, D and Rosset, R'''  (1977) Properties of ribosomes from erythromycin resistant mutants of Escherichia coli.''Mol. Gen. Genet.'' '''156''':267-71
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!align=left  |Abstract
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We have studied the in vitro properties of ribosomes from several mutants resistant to erythromycin. Mutations in three different genes may confer resistance to erythromycin. Two of them are structural genes for proteins L4 and L22 of the large subunit. The third mutation (in eryC gene) seems to affect mainly the small subunit. The mechanism of action of the antibiotic may involve both subunits.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=340907 PubMed]
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!align=left  |Keywords
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Drug Resistance, Microbial; Erythromycin; Escherichia coli; Genes; Ribosomal Proteins; Ribosomes
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="S4fff55bc57274"  class=" tableEdit Phenotype_Table_2" 
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: AT2472
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''rplV''
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*Genotype of Experimental Strain : ''rplV09''
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*Reference Condition: 20C
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*Experimental Condition: 32C is the permissive temperature
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OMP:0000276
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increased resistance to antimicrobial compound
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Erythromycin resistance at the permissive temperatures above 32C
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: AT2472
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''rplD''
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*Genotype of Experimental Strain : ''rplD20''
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*Reference Condition:
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OMP:0000276
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increased resistance to antimicrobial compound
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Erythromycin resistance at the permissive temperatures above 32C
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==Notes==
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ECOID rplV: In vitro liquid broth.
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OMP rplV: erythromycin term made. waiting for approval.
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==References==
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[[Category:Publication]] [[Category:Papers referenced in the LaRossa chapter]] [[Category:LaRossa citations that need review]] [[Category:Erythromycin]]

Latest revision as of 11:26, 7 August 2013

Citation

Pardo, D and Rosset, R (1977) Properties of ribosomes from erythromycin resistant mutants of Escherichia coli.Mol. Gen. Genet. 156:267-71

Abstract

We have studied the in vitro properties of ribosomes from several mutants resistant to erythromycin. Mutations in three different genes may confer resistance to erythromycin. Two of them are structural genes for proteins L4 and L22 of the large subunit. The third mutation (in eryC gene) seems to affect mainly the small subunit. The mechanism of action of the antibiotic may involve both subunits.

Links

PubMed

Keywords

Drug Resistance, Microbial; Erythromycin; Escherichia coli; Genes; Ribosomal Proteins; Ribosomes

edit table

Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: AT2472
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: rplV
  • Genotype of Experimental Strain : rplV09
  • Reference Condition: 20C
  • Experimental Condition: 32C is the permissive temperature

OMP:0000276

increased resistance to antimicrobial compound

Erythromycin resistance at the permissive temperatures above 32C

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: AT2472
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: rplD
  • Genotype of Experimental Strain : rplD20
  • Reference Condition:

OMP:0000276

increased resistance to antimicrobial compound

Erythromycin resistance at the permissive temperatures above 32C


edit table

</protect>

Notes

ECOID rplV: In vitro liquid broth.


OMP rplV: erythromycin term made. waiting for approval.

References

See Help:References for how to manage references in omp dev.

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