PMID:227838

Citation	Alderman, EM , Dills, SS , Melton, T and Dobrogosz, WJ (1979) Cyclic adenosine 3',5'-monophosphate regulation of the bacteriophage T6/colicin K receptor in Escherichia coli. J. Bacteriol. 140:369-76
Abstract	Mutant strains of Escherichia coli unable to synthesize cyclic adenosine 3',5'-monophosphate (cAMP) or the cyclic adenosine monophosphate receptor protein (CRP) were more resistant than wild-type cells to infection by bacteriophage T6. This resistance was found to be associated with the decreased production of specific T6 receptor protein (also the colicin K receptor) located in the outer membrane protein fraction of these cells. Transcription of this particular outer membrane protein was regulated by the cAMP-CRP complex. A novel affinity technique coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used in these investigations.
Links	PubMed PMC216658
Keywords	Bacterial Proteins/biosynthesis; Colicins; Cyclic AMP/physiology; Escherichia coli/metabolism; Mutation; Receptors, Cyclic AMP/physiology; Receptors, Drug/biosynthesis; Receptors, Virus/biosynthesis; Transcription, Genetic
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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: NCR-701	Genotype of Reference Strain: crp in strain NCR-C51	Reference Condition:					Resistance to Phage T6. Table 3.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: NCR-701	Genotype of Reference Strain: cya in strain NCR-C57	Reference Condition:					Resistance to Phage T6. Table 3.
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References

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