PMID:780339

Citation	White, BJ, Hochhauser, SJ, Cintron, NM and Weiss, B (1976) Genetic mapping of xthA, the structural gene for exonuclease III in Escherichia coli K-12.J. Bacteriol. 126:1082-8
Abstract	The genes xthA, pncA, and pabB were ordered relative to others by two- and three-factor transductional crosses with bacteriophage P1. The genes studied span 2 min (2%) of the genetic map of Escherichia coli K-12 in the clockwise sequence pheS-pfkB-xthA-pncA-gap-pabB-fadD. Eleven independently derived xth mutations were examined; all were known to affect exonuclease III and its associated endonuclease II activity, and all were mapped in the xthA region. pncA mutations were found to confer resistance to 6-aminonicotinamide, whereas some pheS mutations are known to specify resistance to p-fluorphenylalanine. xth mutations were readily transferred into other strains by selecting for these co-transducible drug resistance markers.
Links	PubMed
Keywords	6-Aminonicotinamide; Chromosome Mapping; Deoxyribonucleases; Drug Resistance, Microbial; Endonucleases; Escherichia coli; Exonucleases; Genes; Transduction, Genetic; p-Fluorophenylalanine
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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: NCBI Taxon ID: 83333	Genotype of Reference Strain: pncA Genotype of Experimental Strain : pncA	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000034	non-traceable author statement	Resistant to 6-amino-nicotinamide
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